Characterization of the cardiac KCNE1 gene promoter
نویسندگان
چکیده
منابع مشابه
Characterization of the cardiac KCNE1 gene promoter.
BACKGROUND KCNE1 encodes an essential cardiac slow delayed-rectifier potassium current (I(Ks)) beta-subunit (minK). Varying minK expression is important in disease-related remodeling and species-dependent expression. This study addressed 5'-regulatory elements that potentially control KCNE1 transcription. METHODS AND RESULTS The transcriptional start site of human KCNE1 (HKCNE1) was determine...
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fects. Co-expression of KCNE1 (D76N) or KCNE1 (D85N) increases the susceptibility to clarithromycin, a macrolide antibiotic, lowering the IC50 to 1/3–2/3, whereas that of KCNE1 (A8V) decreases the susceptibility, doubling the IC50.1 Coexpression of KCNE1 (A8V), KCNE1 (D76N), or KCNE1 (D85N) increases the susceptibility to cisapride, a gastric prokinetic drug, lowering the IC50 to 1/2.1 Co-expre...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2007
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2006.10.022